TY - BOOK ID - 8508934 TI - Signal transduction in cancer metastasis AU - Wu, Wensheng. AU - Hu, Chi-Tan. PY - 2010 SN - 9048195217 9786613001832 1283001837 9048195225 PB - London : Springer, DB - UniCat KW - Cellular signal transduction. KW - Metastasis. KW - Metastasis KW - Cellular signal transduction KW - Biochemical Processes KW - Cell Physiological Processes KW - Biological Science Disciplines KW - Neoplastic Processes KW - Natural Science Disciplines KW - Biochemical Phenomena KW - Neoplasms KW - Cell Physiological Phenomena KW - Pathologic Processes KW - Chemical Processes KW - Neoplasm Metastasis KW - Signal Transduction KW - Physiology KW - Chemical Phenomena KW - Disciplines and Occupations KW - Diseases KW - Phenomena and Processes KW - Pathological Conditions, Signs and Symptoms KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Cancer KW - Carcinogenesis KW - Research. KW - Oncogenesis KW - Pathogenesis of cancer KW - Tumorigenesis KW - Cancer metastasis KW - Dissemination of cancer KW - Metastases KW - Metastatic cancer KW - Neoplasm metastasis KW - Spread of cancer KW - Tumor dissemination KW - Tumor metastasis KW - Tumor spread KW - Cancer research KW - Pathogenesis KW - Dissemination KW - Medicine. KW - Cancer research. KW - Molecular biology. KW - Oncology. KW - Proteins. KW - Cytokines. KW - Growth factors. KW - Cell biology. KW - Medicine & Public Health. KW - Cancer Research. KW - Molecular Medicine. KW - Cytokines and Growth Factors. KW - Receptors. KW - Cell Biology. KW - Pathology KW - Genetic toxicology KW - Cancer invasiveness KW - Cancer of unknown primary origin KW - Oncology  . KW - Cell receptors. KW - Cytology. KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Cell membrane receptors KW - Cell surface receptors KW - Receptors, Cell KW - Binding sites (Biochemistry) KW - Cell membranes KW - Proteins KW - Cellular immunity KW - Immune response KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Physicians KW - Tumors KW - Regulation KW - Health Workforce KW - Proteins . KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Cell growth factors KW - Cellular growth factors KW - Growth peptides KW - Growth promoting substances KW - Growth substances KW - Peptide growth factors KW - Peptide regulatory factors KW - Polypeptide growth factors KW - Cytokines KW - Peptides KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Systems biology UR - https://www.unicat.be/uniCat?func=search&query=sysid:8508934 AB - The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study. ER -