TY - BOOK ID - 84868793 TI - Free-radical-induced DNA damage and its repair : a chemical perspective AU - Sonntag, C. von AU - 735377 PY - 2006 SN - 9783540261209 9783540305927 3540261206 PB - Berlin ; London : Springer, DB - UniCat KW - DNA damage KW - DNA repair KW - Free radicals (Chemistry) KW - ADN KW - ADN KW - Radicaux libres (Chimie) KW - Lésions KW - Réparation KW - EPUB-LIV-FT LIVBIOLO SPRINGER-B UR - https://www.unicat.be/uniCat?func=search&query=sysid:84868793 AB - Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters. ER -