TY - BOOK ID - 84868478 TI - Inflammation in the Pathogenesis of Chronic Diseases : The COX-2 Controversy AU - Harris, Randall E AU - Bittman, R AU - Dasgupta, D AU - Engelhardt, H AU - Flohe, L AU - Herrmann, H AU - Holzenburg, A AU - Nasheuer, H-P AU - Rottem, S AU - Zwickl, P AU - Wyss, M AU - SpringerLink (Online service) PY - 2007 SN - 9781402056871 9781402056888 PB - Dordrecht Springer Netherlands DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:84868478 AB - In Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy , a panel of leading experts chronicles the evidence supporting the roleofinflammationinthepathogenesisofmajorchronicdiseasesanddiscusses the current controversy regarding beneficial versus adverse effects of selective cyclooxygenase-2(COX-2)inhibitors.Expertsinmultipledisciplinesofmedical research provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine. The book is broadly divided into fivesections. Webeginwithhistoricalperspectivesonthediscoveryanddev- opment of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, including discussion of risk versus benefit and the potential for development of new compounds with better efficacy and safety in the 21st century. This is followed by a section illuminating the role of inflammatory mechanisms in the pathogenesisofarthritis,cardiovasculardisease,cancer,neurodegenerativedisease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Specific chapters then explore the COX-2 controversy  regarding the potential forpositiveversusnegativeimpactofselectiveCOX-2inhibitorsonthecard- vasculature.Recentfindingssuggestthatcardiovascularriskassociatedwithsome COX-2 inhibitors may not be due to a class effect involving COX-2 inhibition, butratherdependsuponthemolecularstructureofspecificcompoundsthathave independenteffectsunrelatedtoCOX-2andprostaglandinbiosynthesis.Important findingsaredocumentedincancerresearchshowingthatselectiveCOX-2inhibitors havepowerfulantineoplasticeffectsagainstmajorformsofcancer.Aspecialsection exploresthecurrentevidencesupportingtheroleofCOX-2andinflammationinthe development of Alzheimer's disease and other neurodegenerative conditions and thepotentialbenefitofcompoundsthatmodulateCOX-2andotherinflammatory cytokines.Thefinalsectionaddressesnutritionalmodulationofinflammationinthe pathogenesisofchronicdiseaseandthechemopreventivevalueofanti-inflammatory nutraceuticalagents. ER -