TY - BOOK ID - 8434511 TI - Life-span extension : single-cell organisms to man AU - Sell, C. AU - Lorenzini, A. AU - Brown-Borg, H. M. PY - 2009 SN - 1603275061 9786612333392 1282333399 160327507X PB - Totowa, N.J. : London : Humana ; Springer [distributor], DB - UniCat KW - Aging -- physiology. KW - Aging. KW - Life Expectancy. KW - Life spans (Biology). KW - Aging KW - Life spans (Biology) KW - Vital Statistics KW - Biological Science Disciplines KW - Growth and Development KW - Data Collection KW - Natural Science Disciplines KW - Physiological Processes KW - Demography KW - Epidemiologic Measurements KW - Epidemiologic Methods KW - Population Characteristics KW - Physiological Phenomena KW - Disciplines and Occupations KW - Information Science KW - Public Health KW - Investigative Techniques KW - Health Care KW - Phenomena and Processes KW - Environment and Public Health KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Life Expectancy KW - Physiology KW - Medicine KW - Biology KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Geriatrics KW - Biophysics KW - Span of life (Biology) KW - Spans, Life (Biology) KW - Age KW - Ageing KW - Senescence KW - Physiological effect KW - Medicine. KW - Geriatrics. KW - Pathology. KW - Medicine & Public Health. KW - Geriatrics/Gerontology. KW - Life (Biology) KW - Developmental biology KW - Gerontology KW - Longevity KW - Age factors in disease UR - https://www.unicat.be/uniCat?func=search&query=sysid:8434511 AB - In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice. Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume. ER -