TY - BOOK ID - 8358923 TI - Molecularly targeted therapy for childhood cancer PY - 2010 SN - 148998142X 0387690603 9786612979408 038769062X 128297940X PB - New York : Springer, DB - UniCat KW - Cancer -- Treatment. KW - Cancer in children -- Treatment. KW - Cancer in children KW - Diseases KW - Age Groups KW - Biological Science Disciplines KW - Therapeutic Uses KW - Drug Therapy KW - Therapeutics KW - Persons KW - Pharmacologic Actions KW - Natural Science Disciplines KW - Antineoplastic Agents KW - Child KW - Neoplasms KW - Pharmacology KW - Molecular Targeted Therapy KW - Disciplines and Occupations KW - Chemical Actions and Uses KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Named Groups KW - Chemicals and Drugs KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Gene therapy KW - Cancer KW - Treatment. KW - Molecular aspects. KW - Childhood cancer KW - Pediatric cancer KW - Medicine. KW - Cancer research. KW - Human genetics. KW - Medical microbiology. KW - Molecular biology. KW - Behavioral sciences. KW - Cell biology. KW - Biomedicine. KW - Cancer Research. KW - Human Genetics. KW - Molecular Medicine. KW - Behavioral Sciences. KW - Cell Biology. KW - Medical Microbiology. KW - Tumors in children KW - Oncology. KW - Animal behavior. KW - Cytology. KW - Microbiology. KW - Microbial biology KW - Biology KW - Microorganisms KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Animals KW - Animals, Habits and behavior of KW - Behavior, Animal KW - Ethology KW - Animal psychology KW - Zoology KW - Ethologists KW - Psychology, Comparative KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Genetics KW - Heredity, Human KW - Physical anthropology KW - Tumors KW - Behavior KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:8358923 AB - Molecularly-Targeted Therapy for Childhood Cancer is a comprehensive exploration of the molecular aspects of childhood cancers that are currently being targeted therapeutically or are in the early phases of development. Each chapter describes key molecular characteristics of hematopoietic malignancies and solid tumors in children and young adults that are fundamental to the etiology, survival and drug resistance of these cancers as well as able to serve as tumor selective pathways for treatment. There has never been a more optimal time to explore the current and future use of molecularly targeted therapies in pediatric oncology. Conventional chemotherapeutic approaches have been dose intensified to such an extent that acute and late toxicities have reached maximal points while the rate of cure has slowed. The volume moves beyond conventional chemotherapeutic approaches to explore approaches that target tumor selective molecular and immunologic characteristics. The chapters further explore how such targeted therapies can begin to be integrated with conventional regimens in order to improve efficacy while reducing morbidity. While molecularly targeted therapies have generated great excitement in the world of oncology, their impact for pediatric patients may provide some of the greatest impact in part because of their developmental susceptibilities to conventional cytotoxic treatments. In addition, less toxic and more effective therapies hold great promise for improving the outcome of pediatric patients in developing countries where supportive care measures may not always be optimal. Molecularly-Targeted Therapy for Childhood Cancer is thus a timely first foray into the world of targeted, pathway directed treatment approaches for pediatric patients with cancer and brings us one step closer to the day when Paul Erhlich’s hope for therapeutic Magic Bullets becomes the conventional approach to cure. ER -