TY - BOOK ID - 8210503 TI - Kisspeptin signaling in reproductive biology AU - Kauffman, Alexander S. AU - Smith, Jeremy T. PY - 2013 SN - 148999839X 1461461987 1461461995 PB - New York : Springer, DB - UniCat KW - Calcitonin gene-related peptide. KW - Drug receptors. KW - Serpins. KW - Tumor suppressor proteins KW - Reproduction KW - Cellular signal transduction KW - Luteinizing hormone releasing hormone KW - Biochemical Processes KW - Reproductive Physiological Processes KW - Biological Science Disciplines KW - Metabolic Phenomena KW - Pituitary Hormone-Releasing Hormones KW - Biochemical Phenomena KW - Hypothalamic Hormones KW - Natural Science Disciplines KW - Phenomena and Processes KW - Reproductive Physiological Phenomena KW - Reproductive and Urinary Physiological Phenomena KW - Chemical Phenomena KW - Peptide Hormones KW - Disciplines and Occupations KW - Hormones KW - Hormones, Hormone Substitutes, and Hormone Antagonists KW - Chemicals and Drugs KW - Signal Transduction KW - Gonadotropin-Releasing Hormone KW - Metabolism KW - Physiology KW - Kisspeptin neurons. KW - Sex differentiatio KW - Endocrine aspects. KW - Kiss1 neurons KW - Kisspeptin-expressing neurons KW - Medicine. KW - Neurosciences. KW - Endocrinology. KW - Reproductive medicine. KW - Biomedicine. KW - Biomedicine general. KW - Reproductive Medicine. KW - Human reproduction KW - Human reproductive health KW - Human reproductive medicine KW - Reproductive medicine KW - Health KW - Internal medicine KW - Neural sciences KW - Neurological sciences KW - Neuroscience KW - Medical sciences KW - Nervous system KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Pathology KW - Physicians KW - Health aspects KW - Neurons KW - Endocrinology . KW - Biomedicine, general. KW - Health Workforce UR - https://www.unicat.be/uniCat?func=search&query=sysid:8210503 AB - Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis. ER -