TY - BOOK ID - 8137234 TI - GPCR signalling complexes : synthesis, assembly, trafficking and specificity AU - Dupre, Denis J. AU - Hebert, Terence E. AU - Jockers, Ralf. PY - 2012 SN - 9400747640 9401780994 9400747659 1283865556 PB - Dordrecht : Springer, DB - UniCat KW - Cell organelles -- Periodicals. KW - Cytochemistry -- Periodicals. KW - G proteins KW - Cellular signal transduction KW - Receptors, Cell Surface KW - Cell Physiological Processes KW - Natural Science Disciplines KW - Biochemical Processes KW - Metabolic Phenomena KW - Phenomena and Processes KW - Cell Physiological Phenomena KW - Chemical Processes KW - Membrane Proteins KW - Biochemical Phenomena KW - Disciplines and Occupations KW - Chemical Phenomena KW - Proteins KW - Amino Acids, Peptides, and Proteins KW - Chemicals and Drugs KW - Receptors, G-Protein-Coupled KW - Signal Transduction KW - Chemistry KW - Metabolism KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Animal Biochemistry KW - Receptors KW - Cellular signal transduction. KW - Receptors. KW - Cellular information transduction KW - Information transduction, Cellular KW - Signal transduction, Cellular KW - GTP-binding proteins KW - GTP regulatory proteins KW - Guanine nucleotide-binding proteins KW - Guanine nucleotide regulatory proteins KW - Medicine. KW - Pharmacology. KW - Medical biochemistry. KW - Proteins. KW - Biomedicine. KW - Biomedicine general. KW - Pharmacology/Toxicology. KW - Medical Biochemistry. KW - Membrane proteins KW - Bioenergetics KW - Cellular control mechanisms KW - Information theory in biology KW - Toxicology. KW - Cell receptors. KW - Biochemistry. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Medical sciences KW - Cell membrane receptors KW - Cell surface receptors KW - Receptors, Cell KW - Binding sites (Biochemistry) KW - Cell membranes KW - Chemicals KW - Medicine KW - Pharmacology KW - Poisoning KW - Poisons KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Pathology KW - Physicians KW - Composition KW - Toxicology KW - Health Workforce KW - Proteins . KW - Biomedicine, general. KW - Medical biochemistry KW - Pathobiochemistry KW - Pathological biochemistry KW - Biochemistry KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Drug effects KW - Medical pharmacology KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Physiological effect KW - Clinical biochemistry. KW - Biomedical Research. KW - Research. KW - Biological research KW - Biomedical research UR - https://www.unicat.be/uniCat?func=search&query=sysid:8137234 AB - This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally? Therefore, the topics to be covered in this book are: 1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis; 2) Assembly of signalling complexes, or subunits of the complex and their organization; 3) GPCR oligomerization; 4) GPCR trafficking; 5) Problems of trafficking: pharmacological chaperones to the rescue. ER -