TY - BOOK ID - 8134775 TI - Tumor-Induced Immune Suppression : Mechanisms and Therapeutic Reversal AU - Gabrilovich, Dmitry I. AU - Hurwitz, Arthur Andrew. PY - 2014 SN - 1489980555 1489980563 PB - New York, NY : Springer New York : Imprint: Springer, DB - UniCat KW - Cytology. KW - Developmental biology. KW - Human genetics. KW - Immunology. KW - Immunosuppression. KW - Immunotherapy -- Methods. KW - Medicine. KW - Microbiology. KW - Tumors KW - Immunosuppression KW - Diseases KW - Lymphocytes KW - Immunomodulation KW - CD4-Positive T-Lymphocytes KW - Investigative Techniques KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Biological Therapy KW - Leukocytes, Mononuclear KW - Leukocytes KW - Therapeutics KW - Blood Cells KW - Immune System KW - Blood KW - Hemic and Immune Systems KW - Cells KW - Anatomy KW - T-Lymphocytes, Regulatory KW - T-Lymphocytes KW - Neoplasms KW - Methods KW - Immunotherapy KW - Medicine KW - Biology KW - Health & Biological Sciences KW - Oncology KW - Microbiology & Immunology KW - Immunological aspects KW - Immunological aspects. KW - Depression, Immune KW - Immune depression KW - Immune suppression KW - Immunodepression KW - Suppression, Immune KW - Tumor immunology KW - Cancer research. KW - Medical microbiology. KW - Cell biology. KW - Biomedicine. KW - Cancer Research. KW - Medical Microbiology. KW - Cell Biology. KW - Human Genetics. KW - Developmental Biology. KW - Immune response KW - Immunological tolerance KW - Immunodeficiency KW - Regulation KW - Oncology. KW - Development (Biology) KW - Growth KW - Ontogeny KW - Genetics KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Cell biology KW - Cellular biology KW - Cytologists KW - Microbial biology KW - Microorganisms KW - Immunobiology KW - Life sciences KW - Serology KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:8134775 AB - Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights. ER -