TY - BOOK ID - 80818826 TI - G protein-coupled receptors AU - Siehler, Sandra AU - Milligan, Graeme PY - 2011 SN - 9780511760334 9780521112086 9780511909917 0511909918 9780511907111 0511907117 0521112087 0511760337 1316086569 1282770888 9786612770883 0511909160 0511905831 0511908415 9781316086568 9781282770881 6612770880 9780511909160 9780511905834 9780511908415 PB - Cambridge Cambridge University Press DB - UniCat KW - G proteins. KW - Cell receptors. KW - Cellular signal transduction. KW - Cellular information transduction KW - Information transduction, Cellular KW - Signal transduction, Cellular KW - Bioenergetics KW - Cellular control mechanisms KW - Information theory in biology KW - Cell membrane receptors KW - Cell surface receptors KW - Receptors, Cell KW - Binding sites (Biochemistry) KW - Cell membranes KW - Proteins KW - GTP-binding proteins KW - GTP regulatory proteins KW - Guanine nucleotide-binding proteins KW - Guanine nucleotide regulatory proteins KW - Membrane proteins KW - Drug delivery systems. KW - Delivery systems, Drug KW - Drug administration technology KW - Drug delivery technology KW - Drugs KW - Pharmaceutical technology KW - Delivery systems UR - https://www.unicat.be/uniCat?func=search&query=sysid:80818826 AB - Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field. ER -