TY - BOOK ID - 8061458 TI - Renal cell carcinoma : translational biology, personalized medicine, and novel therapeutic targets AU - Figlin, Robert A. AU - Rathmell, W. Kimryn. AU - Rini, Brian I. PY - 2012 SN - 1489991395 1461423996 9786613696960 1461424003 1280786574 PB - New York : Springer, DB - UniCat KW - Carcinoma, Renal Cell. KW - Kidney Neoplasms. KW - Renal cell carcinoma. KW - Renal cell carcinoma KW - Urologic Neoplasms KW - Drug Discovery KW - Drug Therapy KW - Adenocarcinoma KW - Kidney Diseases KW - Chemistry, Pharmaceutical KW - Investigative Techniques KW - Urologic Diseases KW - Therapeutics KW - Urogenital Neoplasms KW - Carcinoma KW - Neoplasms, Glandular and Epithelial KW - Male Urogenital Diseases KW - Female Urogenital Diseases KW - Pharmacology KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Neoplasms by Site KW - Chemistry KW - Female Urogenital Diseases and Pregnancy Complications KW - Diseases KW - Natural Science Disciplines KW - Biological Science Disciplines KW - Neoplasms KW - Neoplasms by Histologic Type KW - Disciplines and Occupations KW - Kidney Neoplasms KW - Carcinoma, Renal Cell KW - Drug Design KW - Drug Delivery Systems KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Cancer KW - Treatment. KW - Cancer therapy KW - Cancer treatment KW - Adenocarcinoma of kidney KW - Clear cell carcinoma KW - Grawitz tumor KW - Grawitz's tumor KW - Hypernephroid carcinoma KW - Hypernephroma KW - Renal adenocarcinoma KW - Renal cell adenocarcinoma KW - Therapy KW - Medicine. KW - Cancer research. KW - Pharmacology. KW - Biomedicine. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - Kidneys KW - Oncology. KW - Toxicology. KW - Chemicals KW - Poisoning KW - Poisons KW - Tumors KW - Toxicology KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Cancer research KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:8061458 AB - This volume examines every major topic area in the modern era of renal carcinoma biology and treatment. The unique and intricate genetics of this cancer are highly distinct from most other tumors, and the advances made in this cancer beyond VHL biology have been intrinsically driven by discoveries from familial renal cell carcinomas linked with newer large scale genomic efforts in sporadic disease. These genetic findings fuel strategies to analyze and define sporadic tumors for greater accuracy in prognosis and prediction of response to therapy. Additional topics include major new therapeutic strategies that harness these biological discoveries, in particular angiogenic, energy metabolism, chromatin remodeling, tumor microenvironment, and classical signaling pathways. This text will bring all of these avenues of investigation together for readers interested in understanding the dynamics of this field in the last decade and anticipating a continued steep trajectory in advancements toward the cure of this disease in its many manifestations. ER -