TY - BOOK ID - 8061344 TI - Cell biology of the axon PY - 2009 SN - 3642260306 3642030181 9786613560490 364203019X 1280382589 PB - Heidelberg [Germany] ; New York : Springer Verlag, DB - UniCat KW - Axonal transport. KW - Axons -- Physiology. KW - Axons. KW - Axons KW - Axonal transport KW - Physiology KW - Axonal Transport KW - Cytoplasmic Streaming KW - Neurons KW - Cell Surface Extensions KW - Nerve Fibers KW - Nervous System Physiological Processes KW - Biological Science Disciplines KW - Nervous System Physiological Phenomena KW - Cells KW - Cellular Structures KW - Natural Science Disciplines KW - Biological Transport KW - Cell Physiological Processes KW - Anatomy KW - Cell Physiological Phenomena KW - Metabolism KW - Disciplines and Occupations KW - Musculoskeletal and Neural Physiological Phenomena KW - Nervous System KW - Metabolic Phenomena KW - Phenomena and Processes KW - Neuroscience KW - Cytology KW - Human Anatomy & Physiology KW - Biology KW - Health & Biological Sciences KW - Physiology. KW - Nerve axons KW - Axonal flow KW - Axoplasmic flow KW - Axoplasmic transport KW - Flow, Axoplasmic KW - Neuroplasmic flow KW - Transport, Axonal KW - Life sciences. KW - Neurochemistry. KW - Biochemistry. KW - Cell biology. KW - Life Sciences. KW - Cell Biology. KW - Biochemistry, general. KW - Biological transport KW - Protoplasmic streaming KW - Cytology. KW - Biochemistry KW - Neurosciences KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Medical sciences KW - Cell biology KW - Cellular biology KW - Cytologists KW - Composition UR - https://www.unicat.be/uniCat?func=search&query=sysid:8061344 AB - Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration. Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities. ER -