TY - BOOK ID - 8060680 TI - T[subscript h]17 cells in health and disease PY - 2011 SN - 1489997342 1441993703 9786613292117 1441993711 1283292114 PB - New York : Springer, DB - UniCat KW - Allergy. KW - Diseases. KW - Health. KW - Immunity. KW - Immunology. KW - T cells KW - Cellular control mechanisms KW - Immune response KW - Inflammation KW - Interleukins KW - T-Lymphocytes, Helper-Inducer KW - Pathologic Processes KW - Diseases KW - CD4-Positive T-Lymphocytes KW - Cytokines KW - Pathological Conditions, Signs and Symptoms KW - Intercellular Signaling Peptides and Proteins KW - T-Lymphocytes KW - Lymphocytes KW - Biological Factors KW - Peptides KW - Proteins KW - Amino Acids, Peptides, and Proteins KW - Chemicals and Drugs KW - Leukocytes, Mononuclear KW - Leukocytes KW - Blood Cells KW - Immune System KW - Blood KW - Cells KW - Hemic and Immune Systems KW - Anatomy KW - Immune System Diseases KW - Interleukin-17 KW - Th17 Cells KW - Biology KW - Health & Biological Sciences KW - Microbiology & Immunology KW - Regulation KW - Immunological aspects KW - Th1 cells KW - T cells. KW - T lymphocytes KW - Thymus-dependent cells KW - Thymus-dependent lymphocytes KW - Thymus-derived cells KW - Th1 helper cells KW - Th1 helper lymphocytes KW - Th1 lymphocytes KW - Th17 cells KW - Th17 cells. KW - T helper 17 cells KW - T helper 17 lymphocytes KW - Th-17 cells KW - Th17 lymphocytes KW - Type 17 helper T cells KW - Medicine. KW - Pharmaceutical technology. KW - Infectious diseases. KW - Cell biology. KW - Biomedicine. KW - Infectious Diseases. KW - Cell Biology. KW - Medicine/Public Health, general. KW - Pharmaceutical Sciences/Technology. KW - Emerging infectious diseases. KW - Cytology. KW - Pharmaceutical laboratory techniques KW - Pharmaceutical laboratory technology KW - Technology, Pharmaceutical KW - Technology KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Cell biology KW - Cellular biology KW - Cytologists KW - Emerging infections KW - New infectious diseases KW - Re-emerging infectious diseases KW - Reemerging infectious diseases KW - Communicable diseases KW - Immunobiology KW - Serology KW - Health Workforce UR - https://www.unicat.be/uniCat?func=search&query=sysid:8060680 AB - “About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation.   However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune tissue inflammation.   The discovery of TH17 cells has expanded the TH1 / TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector T cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings.”   - From Chapter One by Vijay K. Kuchroo, Harvard University, USA       “The recently identified Interleukin 17 (IL-17) cytokine family contributes to immunity to infectious diseases and chronic inflammatory diseases. Further studies on the regulation and function of this important cytokine family may provide better understanding on the roles of the IL-17 family in immune-mediated diseases; such knowledge may lead to the development of immunotherapeutic strategies for treatment of several inflammatory diseases.”   - From Chapter Two by Chen Dong, University of Texas and MD Anderson Cancer Center, USA. ER -