TY - BOOK ID - 8060404 TI - CCN proteins in health and disease : an overview of the fifth international workshop on the CCN family of genes AU - Perbal, Annick. AU - Takigawa, Masaharu. AU - Perbal, Bernard V. AU - International Workshop on the CCN Family of Genes PY - 2010 SN - 904813790X 9048137780 9786612924729 9048137799 9401782911 1282924729 PB - New York : Springer, DB - UniCat KW - Cell differentiation -- Molecular aspects -- Congresses. KW - Growth factors -- Congresses. KW - Protein-protein interactions -- Congresses. KW - Protein-protein interactions KW - Cell differentiation KW - Growth factors KW - Intercellular Signaling Peptides and Proteins KW - Extracellular Matrix Proteins KW - Publication Formats KW - CCN Intercellular Signaling Proteins KW - Congresses KW - Biological Factors KW - Peptides KW - Proteins KW - Scleroproteins KW - Publication Characteristics KW - Chemicals and Drugs KW - Amino Acids, Peptides, and Proteins KW - Human Anatomy & Physiology KW - Animal Biochemistry KW - Health & Biological Sciences KW - Molecular aspects KW - Interactions, Protein-protein KW - Protein interactions KW - Cell fate specification KW - Cell specification KW - Cells KW - Differentiation of cells KW - Fate specification of cells KW - Specification of cells KW - Differentiation KW - Fate specification KW - Specification KW - Medicine. KW - Medical genetics. KW - Molecular biology. KW - Proteins. KW - Cell biology. KW - Biomedicine. KW - Biomedicine general. KW - Gene Function. KW - Molecular Medicine. KW - Protein Science. KW - Cell Biology. KW - Morphogenesis KW - Molecular association KW - Biochemistry. KW - Cytology. KW - Cell biology KW - Cellular biology KW - Biology KW - Cytologists KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Medical sciences KW - Clinical genetics KW - Diseases KW - Heredity of disease KW - Human genetics KW - Pathology KW - Genetic disorders KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Physicians KW - Composition KW - Genetic aspects KW - Health Workforce KW - Proteins . KW - Biomedicine, general. KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Systems biology UR - https://www.unicat.be/uniCat?func=search&query=sysid:8060404 AB - The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field. ER -