TY - BOOK ID - 8057523 TI - Advancing methods for biomolecular crystallography. PY - 2013 SN - 9400762313 9400762321 PB - New York, New York : Springer, DB - UniCat KW - Chemistry. KW - Spectroscopy. KW - Chemistry, Organic. KW - Biochemistry. KW - Crystallography. KW - Spectroscopy/Spectrometry. KW - Protein Structure. KW - Organic Chemistry. KW - Chemistry KW - Physical Sciences & Mathematics KW - Analytical Chemistry KW - Leptology KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Organic chemistry KW - Analysis, Spectrum KW - Spectra KW - Spectrochemical analysis KW - Spectrochemistry KW - Spectroscopy KW - Composition KW - Organic chemistry. KW - Proteins. KW - Crystallography and Scattering Methods. KW - Physical sciences KW - Mineralogy KW - Chemistry, Analytic KW - Interferometry KW - Optics KW - Radiation KW - Wave-motion, Theory of KW - Absorption spectra KW - Light KW - Spectroscope KW - Biology KW - Medical sciences KW - Qualitative KW - Spectrometry KW - Proteins . KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Analytical chemistry KW - Analytical biochemistry. KW - Analytic biochemistry KW - Bioanalytic chemistry KW - Bioanalytical chemistry KW - Biochemistry UR - https://www.unicat.be/uniCat?func=search&query=sysid:8057523 AB - This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web.  Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis.  These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome.  Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored. ER -