TY - BOOK ID - 7988195 TI - PI3K-mTOR in Cancer and Cancer Therapy AU - Dey, Nandini. AU - De, Pradip. AU - Leyland-Jones, Brian. PY - 2016 SN - 3319342096 3319342118 PB - Cham : Springer International Publishing : Imprint: Humana, DB - UniCat KW - Medicine. KW - Cancer research. KW - Drug resistance. KW - Molecular biology. KW - Biomedicine. KW - Cancer Research. KW - Molecular Medicine. KW - Drug Resistance. KW - Cancer KW - Molecular aspects. KW - Treatment. KW - Cancer therapy KW - Cancer treatment KW - Therapy KW - Oncology. KW - Drug interactions. KW - Interactions, Drug KW - Drugs KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Tumors KW - Side effects KW - Health Workforce KW - Resistance to drugs KW - Pharmacology KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:7988195 AB - In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area. ER -