TY - BOOK ID - 7987329 TI - Radiation proteomics : the effects of ionizing and non-ionizing radiation on cells and tissues PY - 2013 VL - v. 990 SN - 9400758952 9400758960 1299408184 9781299408180 9789400758964 PB - Dordrecht ; New York : Springer, DB - UniCat KW - Models, Genetic. KW - Proteins -- Structure. KW - Proteomics. KW - Proteomics KW - Proteins KW - Anatomy KW - Biochemistry KW - Investigative Techniques KW - Radiation KW - Amino Acids, Peptides, and Proteins KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Biological Science Disciplines KW - Electromagnetic Phenomena KW - Physical Phenomena KW - Natural Science Disciplines KW - Chemicals and Drugs KW - Phenomena and Processes KW - Disciplines and Occupations KW - Cells KW - Methods KW - Radiation, Nonionizing KW - Radiation Effects KW - Radiation, Ionizing KW - Tissues KW - Proteome KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Animal Biochemistry KW - Effect of radiation on KW - Effect of radiation on. KW - Proteids KW - Medicine. KW - Radiation protection. KW - Biomedicine. KW - Biomedicine general. KW - Effects of Radiation/Radiation Protection. KW - Safety measures. KW - Molecular biology KW - Radiation monitoring KW - Radiation protection KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Biomolecules KW - Polypeptides KW - Environmental protection. KW - Environmental quality management KW - Protection of environment KW - Environmental sciences KW - Applied ecology KW - Environmental engineering KW - Environmental policy KW - Environmental quality KW - Health Workforce KW - Radiation—Safety measures. KW - Biomedicine, general. UR - https://www.unicat.be/uniCat?func=search&query=sysid:7987329 AB - Proteomics is widely used in search of biomarkers, pharmacology, clinical research and toxicology. With the help of proteomics large amount of information about the physiology of living cells can be obtained in a single experiment. Combining this information with data from genomics and other high-throughput screening techniques like transcriptomics and metabolomics allows gaining new insights into physiology of life and diseases. The area of research that is still waiting for the proteomics “boom” is the search for the biological effects of radiation. It is relatively much known about the effects of high doses of radiation, both ionizing and non-ionizing. However, much less is known about the effects of low or very low doses of radiation, to which people are often exposed in their every day life. The effects of the low doses of ionizing radiation (e.g. bystander effect) or low doses of non-ionizing radiation (e.g. effect of radiation emitted by wireless communication devices) are not yet reliably established. Often these effects are small and difficult to discover and to replicate. One of the limiting factors in the research of low dose radiation effects is often the lack of the knowledge of the cellular target molecules. Proteomics, the high-throughput screening of expression and activity of proteins is very well suited for the research aiming at discovery of molecular targets of low dose radiation. Proteomics approach seems to be particularly well suited for studying biological effects of low dose radiation because it might reveal effects that are not possible to predict based on the presently available knowledge concerning the effects of the high doses of radiation. Search through the published scientific literature shows that to date was published only a very limited number of proteomics studies examining effects of radiation. This book, Radiation Proteomics, presents the current status the research of radiation effects using proteomics approach. The book begins with the review of current status and the future direction in the development of proteomics methods. This is followed by chapters dealing with the effects of ionizing and non-ionizing radiation on cells, tissues and body fluids. The editor of the book, Research Professor Dariusz Leszczynski, is known for studies that introduced, some 10 years ago, the high-throughput screening techniques of proteomics and transcriptomics into the main stream of the research on the biological effects of the non-ionizing radiation emitted by the wireless communication devices. In recent years he has also done studies examining effects of low-dose ionizing radiation on cellular proteome. ER -