TY - BOOK ID - 7914090 TI - Diabetes, insulin and Alzheimer's disease AU - Christen, Yves. AU - Craft, Suzanne. AU - Colloque médecine et recherche AU - Colloque médecine et recherche AU - Fondation IPSEN pour la recherche thérapeutique. PY - 2010 SN - 3642042996 9786612830785 3642043003 1282830783 PB - Berlin ; Heidelberg : Springer-Verlag, DB - UniCat KW - Aged -- Congresses. KW - Alzheimer's disease -- Endocrine aspects -- Congresses. KW - Diabetes -- Complications -- Congresses. KW - Insulin -- physiology -- Congresses. KW - Adult KW - Diabetes Mellitus KW - Dementia KW - Publication Formats KW - Proinsulin KW - Biological Science Disciplines KW - Tauopathies KW - Alzheimer Disease KW - Insulin KW - Diabetes Mellitus, Type 2 KW - Aged KW - Physiology KW - Congresses KW - Glucose Metabolism Disorders KW - Publication Characteristics KW - Pancreatic Hormones KW - Neurodegenerative Diseases KW - Age Groups KW - Delirium, Dementia, Amnestic, Cognitive Disorders KW - Brain Diseases KW - Endocrine System Diseases KW - Natural Science Disciplines KW - Metabolic Diseases KW - Central Nervous System Diseases KW - Peptide Hormones KW - Nervous System Diseases KW - Mental Disorders KW - Diseases KW - Persons KW - Disciplines and Occupations KW - Psychiatry and Psychology KW - Named Groups KW - Nutritional and Metabolic Diseases KW - Hormones KW - Peptides KW - Amino Acids, Peptides, and Proteins KW - Hormones, Hormone Substitutes, and Hormone Antagonists KW - Chemicals and Drugs KW - Medicine KW - Neurology KW - Clinical Endocrinology KW - Health & Biological Sciences KW - Diabetes KW - Alzheimer's disease. KW - Treatment. KW - Alzheimer disease KW - Alzheimer's dementia KW - Medicine. KW - Neurosciences. KW - Endocrinology. KW - Geriatrics. KW - Biomedicine. KW - Geriatrics/Gerontology. KW - Basal ganglia KW - Presenile dementia KW - Senile dementia UR - https://www.unicat.be/uniCat?func=search&query=sysid:7914090 AB - Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects. ER -