TY - BOOK ID - 7913241 TI - Stem cells and prostate cancer PY - 2013 SN - 1493900943 1461464978 1461464986 PB - New York : Springer, DB - UniCat KW - Prostate -- Cancer -- Genetic aspects. KW - Stem cells. KW - Prostate KW - Biology KW - Genital Neoplasms, Male KW - Stem Cells KW - Cells KW - Biological Science Disciplines KW - Urogenital Neoplasms KW - Anatomy KW - Natural Science Disciplines KW - Neoplasms by Site KW - Neoplasms KW - Disciplines and Occupations KW - Diseases KW - Prostatic Neoplasms KW - Neoplastic Stem Cells KW - Genetics KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Genetic aspects KW - Cancer KW - Genetic aspects. KW - Colony-forming units (Cells) KW - Mother cells KW - Progenitor cells KW - Medicine. KW - Cancer research. KW - Cell biology. KW - Biomedicine. KW - Cancer Research. KW - Cell Biology. KW - Biomedicine general. KW - Oncology. KW - Cytology. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Cell biology KW - Cellular biology KW - Cytologists KW - Tumors KW - Health Workforce KW - Biomedicine, general. KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:7913241 AB - Recent evidence demonstrates that normal prostate tissue contains stem cells.  There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells.  Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer.  This book will explore the role of stem cells in normal prostate development and prostate cancer, methods for isolation and characterization of normal prostate stem cells and prostate tumor initiating cells, the functional relationship between normal stem cells and prostate tumor initiating cells, the relationship of prostate cancer genetics and self-renewal and differentiation, the prostate stem cell as a target for therapeutics and prevention, and the utility of stem cells for prostate cancer models.  This book synthesizes these concepts and more into a single volume accessible to basic and translational researchers in prostate cancer and beyond. ER -