TY - BOOK ID - 78644961 TI - Macrolides AU - Arsic, Biljana, AU - Arsic, Biljana AU - Barber, Jill AU - Kragol, Goran AU - Novak, Predrag AU - Rimoli, Maria Grazia AU - Sodano, Federica PY - 2018 SN - 3110515040 311051575X 9783110515756 9783110515046 9783110515022 3110515024 9783110515763 3110515768 9783110515763 PB - Berlin Boston DB - UniCat KW - Antibacterial agents. KW - Macrolide antibiotics. KW - Antibiotikum. KW - Makrocyclische Verbindungen. KW - Makrolidantibiotikum. KW - Makrolide. KW - SCIENCE / Chemistry / Organic. KW - Macrolides KW - Antibiotics KW - Lactones KW - Macrocyclic compounds KW - Anti-bacterial agents KW - Antibacterials KW - Bacteriocidal agents KW - Bacteriostatic agents KW - Anti-infective agents KW - Bacterial diseases KW - Bactericides KW - Chemotherapy UR - https://www.unicat.be/uniCat?func=search&query=sysid:78644961 AB - Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance. ER -