TY - BOOK ID - 7839219 TI - Gadd45 Stress Sensor Genes AU - Liebermann, Dan A. AU - Hoffman, Barbara. PY - 2013 SN - 1461482887 1461482895 PB - New York, NY : Springer New York : Imprint: Springer, DB - UniCat KW - Genes. KW - Human molecular genetics KW - Protein-protein interactions KW - Cellular signal transduction KW - Peptides KW - Proteins KW - Biological Science Disciplines KW - Metabolic Phenomena KW - Physiological Processes KW - Natural Science Disciplines KW - Physiological Phenomena KW - Amino Acids, Peptides, and Proteins KW - Phenomena and Processes KW - Chemicals and Drugs KW - Disciplines and Occupations KW - Stress, Physiological KW - Cell Cycle Proteins KW - Intracellular Signaling Peptides and Proteins KW - Metabolism KW - Physiology KW - Medicine KW - Biology KW - Health & Biological Sciences KW - Pathology KW - Genetics KW - Medicine. KW - Human genetics. KW - Medical genetics. KW - Biochemistry. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Clinical genetics KW - Diseases KW - Heredity of disease KW - Clinical sciences KW - Medical profession KW - Composition KW - Genetic aspects KW - Biomedicine. KW - Gene Function. KW - Biochemistry, general. KW - Human Genetics. KW - Chemistry KW - Medical sciences KW - Human genetics KW - Genetic disorders KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Life sciences KW - Physicians UR - https://www.unicat.be/uniCat?func=search&query=sysid:7839219 AB - Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  . ER -