TY - BOOK ID - 7837812 TI - Self and nonself PY - 2012 SN - 1461416795 9786613696823 1280786434 1461416809 PB - New York : Springer Science+Business Media, DB - UniCat KW - Cellular recognition. KW - Immunologic memory. KW - Natural immunity. KW - Immunity KW - Immune Tolerance KW - Immunomodulation KW - Immune System Phenomena KW - Phenomena and Processes KW - Immune System Processes KW - Immunity, Innate KW - Adaptive Immunity KW - Self Tolerance KW - Biology KW - Health & Biological Sciences KW - Microbiology & Immunology KW - Immunity. KW - Medicine. KW - Immunology. KW - Biomedicine. KW - Biomedicine general. KW - Immunobiology KW - Life sciences KW - Serology KW - Clinical sciences KW - Medical profession KW - Human biology KW - Medical sciences KW - Pathology KW - Physicians KW - Immunology KW - Biomedicine, general. KW - Health Workforce UR - https://www.unicat.be/uniCat?func=search&query=sysid:7837812 AB - In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes. ER -