TY - BOOK ID - 77890077 TI - Innovative drug development for headache disorders AU - Olesen, Jes. AU - Ramadan, Nabih. PY - 2008 SN - 0191768839 1283580446 9786613892898 0191564621 9780191564628 9780199552764 0199552762 PB - Oxford ; New York : Oxford University Press, DB - UniCat KW - Analgesics. KW - Drug development. KW - Headache KW - Head pain KW - Head KW - Pain KW - Development of drugs KW - Drugs KW - New drug development KW - Pharmacology KW - Pharmacy KW - Analgetics KW - Anodynes KW - Pain-killing drugs KW - Pain relievers KW - Painkillers KW - Central nervous system depressants KW - Chemotherapy. KW - Diseases KW - Development UR - https://www.unicat.be/uniCat?func=search&query=sysid:77890077 AB - Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do nottolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are no ER -