TY - BOOK ID - 77869640 TI - Meselson, Stahl, and the replication of DNA PY - 2001 SN - 1281730459 9786611730451 0300129661 9780300129663 9781281730459 9780300085402 0300085400 PB - New Haven, CT Yale University Press DB - UniCat KW - DNA replication KW - Molecular biology KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Chromosomal DNA replication KW - DNA KW - Replication of DNA KW - Experiments KW - History. KW - Replication KW - Synthesis KW - Meselson, Matthew. KW - Stahl, Franklin W. UR - https://www.unicat.be/uniCat?func=search&query=sysid:77869640 AB - In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment. ER -