TY - BOOK ID - 7764971 TI - Quasispecies: From Theory to Experimental Systems AU - Domingo, Esteban. AU - Schuster, P. PY - 2016 SN - 3319238973 3319238981 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Immunology. KW - Microbiology & Immunology KW - Biology KW - Health & Biological Sciences KW - Virology. KW - RNA viruses. KW - Species. KW - Speciation (Biology) KW - Riboviruses KW - Viruses, RNA KW - Microbiology KW - Viruses KW - Genetics KW - Hybridization KW - Organisms KW - Medical virology. KW - Human genetics. KW - Human Genetics. KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Immunobiology KW - Life sciences KW - Serology KW - Medical microbiology KW - Virology KW - Virus diseases UR - https://www.unicat.be/uniCat?func=search&query=sysid:7764971 AB - This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. . ER -