TY - BOOK ID - 7763373 TI - Endocrine FGFs and klothos PY - 2012 SN - 1461408865 9786613696793 128078640X 1461408873 PB - New York : Austin, Tex. : Springer Science+Business Media ; Landes Bioscience, DB - UniCat KW - Endocrine toxicology. KW - Fibroblast growth factors. KW - Protein binding. KW - Receptors, Growth Factor KW - Anatomy KW - Glycoside Hydrolases KW - Intercellular Signaling Peptides and Proteins KW - Metabolic Phenomena KW - Peptides KW - Proteins KW - Receptors, Peptide KW - Biological Factors KW - Hydrolases KW - Phenomena and Processes KW - Enzymes KW - Amino Acids, Peptides, and Proteins KW - Receptors, Cell Surface KW - Chemicals and Drugs KW - Membrane Proteins KW - Enzymes and Coenzymes KW - Metabolism KW - Receptors, Fibroblast Growth Factor KW - Fibroblast Growth Factors KW - Endocrine System KW - Glucuronidase KW - Biology KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Cytology KW - Animal Biochemistry KW - Fibroblast growth factors KW - Endocrinology. KW - Endocrine aspects. KW - Metabolism. KW - Fibroblast growth factor KW - Life sciences. KW - Gene expression. KW - Cell biology. KW - Life Sciences. KW - Cell Biology. KW - Gene Expression. KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Genes KW - Genetic regulation KW - Biosciences KW - Sciences, Life KW - Science KW - Expression KW - Growth factors KW - Mitogens KW - Internal medicine KW - Hormones KW - Cytology. UR - https://www.unicat.be/uniCat?func=search&query=sysid:7763373 AB - "Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors"--Provided by publisher. ER -