TY - BOOK ID - 7691790 TI - FGF signalling in vertebrate development AU - Pownall, Mary Elizabeth. AU - Isaacs, Harry V. PY - 2010 SN - 1615040633 1615040641 PB - [San Rafael, Calif.?] : Morgan & Claypool Life Sciences, DB - UniCat KW - Fibroblast growth factors. KW - Vertebrates -- Development. KW - Vertebrates -- Growth & development. KW - Fibroblast Growth Factors KW - Chordata KW - Intercellular Signaling Peptides and Proteins KW - Animals KW - Biological Factors KW - Proteins KW - Eukaryota KW - Peptides KW - Amino Acids, Peptides, and Proteins KW - Organisms KW - Chemicals and Drugs KW - Fibroblast Growth Factor 1 KW - Vertebrates KW - Zoology KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Animal Biochemistry KW - Animal Anatomy & Embryology KW - Growth factors. KW - Growth. KW - Fibroblast Growth Factors. KW - growth & development. KW - Fibroblast growth factor KW - Mesoderm KW - Neurectoderm KW - Xenopus KW - Organogenesis KW - Somites KW - Limb KW - MyoD KW - Somitogenesis KW - Morphogenesis KW - Left-right asymmetry KW - MAPK KW - Sprouty KW - ERK KW - Map kinase phosphatase KW - Signal transduction UR - https://www.unicat.be/uniCat?func=search&query=sysid:7691790 AB - The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry. ER -