TY - BOOK ID - 7688676 TI - Myocardial tissue engineering AU - Boccaccini, A. R. AU - Harding, Sian E. PY - 2011 SN - 3642180558 9786613366610 1283366614 3642180566 PB - New York : Springer, DB - UniCat KW - Tissue engineering KW - Cardiovascular system KW - Culture Techniques KW - Heart KW - Myocardial Ischemia KW - Muscles KW - Investigative Techniques KW - Muscle, Striated KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Clinical Laboratory Techniques KW - Heart Diseases KW - Musculoskeletal System KW - Vascular Diseases KW - Cardiovascular System KW - Cardiovascular Diseases KW - Tissues KW - Anatomy KW - Diseases KW - Tissue Engineering KW - Myocardium KW - Myocardial Infarction KW - Methods KW - Health & Biological Sciences KW - Biomedical Engineering KW - Treatment KW - Myocardium. KW - Tissue engineering. KW - Cardiac muscle KW - Heart muscle KW - Muscle KW - Engineering. KW - Gene therapy. KW - Cardiology. KW - Stem cells. KW - Biomedical engineering. KW - Biomaterials. KW - Biomedical Engineering. KW - Stem Cells. KW - Gene Therapy. KW - Biomedical engineering KW - Regenerative medicine KW - Tissue culture KW - Biomedical Engineering and Bioengineering. KW - Therapy, Gene KW - Genetic engineering KW - Therapeutics KW - Biocompatible materials KW - Biomaterials KW - Medical materials KW - Medicine KW - Materials KW - Biocompatibility KW - Prosthesis KW - Colony-forming units (Cells) KW - Mother cells KW - Progenitor cells KW - Cells KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Biophysics KW - Engineering KW - Internal medicine KW - Bioartificial materials KW - Hemocompatible materials KW - Biomaterials (Biomedical materials) UR - https://www.unicat.be/uniCat?func=search&query=sysid:7688676 AB - Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE. ER -