TY - BOOK ID - 7685921 TI - Pancreatic Islet Isolation : From the Mouse to the Clinic PY - 2016 SN - 3319398229 3319398245 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Life sciences. KW - Endocrinology. KW - Cell biology. KW - Animal models in research. KW - Biomedical engineering. KW - Life Sciences. KW - Cell Biology. KW - Biomedical Engineering. KW - Animal Models. KW - Islands of Langerhans. KW - Pancreas. KW - Endocrine pancreas KW - Islet cells KW - Islets of Langerhans KW - Langerhans, Islands of KW - Pancreatic islets KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Biophysics KW - Engineering KW - Medicine KW - Animal experimentation KW - Biological models KW - Laboratory animals KW - Research KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Internal medicine KW - Hormones KW - Biosciences KW - Sciences, Life KW - Science KW - Digestive organs KW - Endocrine glands KW - Exocrine glands KW - Pancreas KW - Cytology. KW - Laboratory animals. KW - Biomedical Engineering and Bioengineering. KW - Animals, Experimental KW - Animals, Laboratory KW - Animals in research KW - Experimental animals KW - Lab animals KW - Animal culture KW - Laboratory organisms KW - Working animals KW - Endocrinology . UR - https://www.unicat.be/uniCat?func=search&query=sysid:7685921 AB - Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate “work of a craftsman”. This book, which is aimed at beginners and experts alike, is a survey of the current state-of–the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications. ER -