TY - BOOK ID - 7616567 TI - Handbook on immunosenescence : basic understanding and clinical applications PY - 2009 SN - 1402090625 1402090633 PB - New York : Springer, DB - UniCat KW - Developmental immunology. KW - Immune system --Aging. KW - Immune system KW - Developmental immunology KW - Microbiology & Immunology KW - Biology KW - Health & Biological Sciences KW - Aging KW - Aging. KW - Immunological aspects. KW - Immunological system KW - Medicine. KW - Immunology. KW - Geriatrics. KW - Biomedicine. KW - Biomedicine general. KW - Geriatrics/Gerontology. KW - Anatomy KW - Immunology KW - Medicine KW - Gerontology KW - Older people KW - Immunobiology KW - Life sciences KW - Serology KW - Clinical sciences KW - Medical profession KW - Human biology KW - Medical sciences KW - Pathology KW - Physicians KW - Diseases KW - Health and hygiene KW - Health Workforce KW - Biomedicine, general. UR - https://www.unicat.be/uniCat?func=search&query=sysid:7616567 AB - “Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”. ER -