TY - BOOK ID - 7611860 TI - Cardiovascular Safety in Drug Development and Therapeutic Use : New Methodologies and Evolving Regulatory Landscapes AU - Turner, J. Rick. AU - Karnad, Dilip R. AU - Kothari, Snehal. PY - 2017 SN - 3319403451 3319403478 PB - Cham : Springer International Publishing : Imprint: Adis, DB - UniCat KW - Medicine. KW - Cardiology. KW - Pharmacy. KW - Medicine & Public Health. KW - Drug Safety and Pharmacovigilance. KW - Drugs KW - Drug development. KW - Side effects. KW - Development of drugs KW - New drug development KW - Adverse drug reactions KW - Adverse reactions to drug therapy KW - Chemotherapy KW - Drug-induced disease KW - Drug side effects KW - Side effects of drugs KW - Development KW - Complications KW - Adverse reactions KW - Pharmacology KW - Pharmacy KW - Iatrogenic diseases KW - Drug interactions KW - Physiological effect KW - Heart KW - Internal medicine KW - Diseases KW - Chemistry KW - Medicine KW - Materia medica UR - https://www.unicat.be/uniCat?func=search&query=sysid:7611860 AB - With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects. This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training. Peter R. Kowey, MD, FACC, FAHA, FHRS Lankenau Institute for Medical Research & Thomas Jefferson University. ER -