TY - BOOK ID - 7581608 TI - Protein structure, stability, and folding PY - 2001 SN - 0896036820 0585402248 128082154X 9786610821549 1592591930 9780896036826 1617371327 PB - Totowa, NJ : Humana Press : Imprint: Humana, DB - UniCat KW - Protein folding. KW - Proteins KW - Conformation. KW - Protein conformation KW - Folding of proteins KW - Folding KW - Conformation KW - Biochemistry. KW - Biochemistry, general. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Medical sciences KW - Composition KW - Protein folding KW - Protein Conformation KW - Protein Folding KW - Structure-Activity Relationship KW - 577.122 KW - Protein Folding, Globular KW - Folding, Globular Protein KW - Folding, Protein KW - Foldings, Globular Protein KW - Foldings, Protein KW - Globular Protein Folding KW - Globular Protein Foldings KW - Protein Foldings KW - Protein Foldings, Globular KW - Proteostasis KW - Protein Multimerization KW - Intrinsically Disordered Proteins KW - Conformation, Protein KW - Conformations, Protein KW - Protein Conformations KW - 577.122 Protein metabolism KW - Protein metabolism KW - Relationship, Structure-Activity KW - Relationships, Structure-Activity KW - Structure Activity Relationship KW - Structure-Activity Relationships KW - chemistry KW - PROTEINS KW - PROTEIN FOLDING KW - CONFORMATION UR - https://www.unicat.be/uniCat?func=search&query=sysid:7581608 AB - With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today. ER -