TY - BOOK ID - 7538249 TI - Chemokine receptors in Cancer PY - 2009 SN - 1617378852 1603272666 9786612331046 1282331043 1603272674 PB - Totowa, NJ : Humana Press, DB - UniCat KW - Cancer cells KW - Chemokines KW - Receptors, Cytokine KW - Antigens, CD KW - Receptors, G-Protein-Coupled KW - Diseases KW - Angiogenesis Modulating Agents KW - Growth Substances KW - Receptors, Immunologic KW - Antigens, Differentiation KW - Receptors, Cell Surface KW - Membrane Proteins KW - Biological Markers KW - Antigens, Surface KW - Physiological Effects of Drugs KW - Pharmacologic Actions KW - Proteins KW - Antigens KW - Biological Factors KW - Amino Acids, Peptides, and Proteins KW - Chemicals and Drugs KW - Chemical Actions and Uses KW - Angiogenesis Inducing Agents KW - Neoplasms KW - Receptors, Chemokine KW - Biology KW - Health & Biological Sciences KW - Medicine KW - Pharmacy, Therapeutics, & Pharmacology KW - Oncology KW - Microbiology & Immunology KW - Growth KW - Regulation. KW - Receptors KW - Effect of drugs on. KW - Effect of drugs on KW - Regulation KW - Chemokines. KW - Drug receptors. KW - Drugs KW - Receptors, Drug KW - Chemotactic cytokines KW - Inflammatory peptides KW - Intercrines KW - Medicine. KW - Cancer research. KW - Oncology. KW - Biomedicine. KW - Cancer Research. KW - Cell receptors KW - Cytokines KW - Inflammation KW - Peptides KW - Mediators KW - Oncology  . KW - Tumors KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:7538249 AB - Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed. ER -