TY - BOOK ID - 704963 TI - Metronomic Chemotherapy : Pharmacology and Clinical Applications AU - Bocci, Guido. AU - Francia, Giulio. PY - 2014 SN - 3662436043 3662436035 PB - Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, DB - UniCat KW - Chemotherapy. KW - Drug therapy KW - Pharmacotherapy KW - Therapeutics KW - Drugs KW - Pharmacology KW - Toxicology. KW - Oncology . KW - Oncology. KW - Pharmacology/Toxicology. KW - Cancer Research. KW - Tumors KW - Chemicals KW - Medicine KW - Poisoning KW - Poisons KW - Toxicology KW - Pharmacology. KW - Cancer research. KW - Cancer research KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemotherapy KW - Pharmacy KW - Physiological effect UR - https://www.unicat.be/uniCat?func=search&query=sysid:704963 AB - This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoenconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic. ER -