TY - BOOK ID - 700868 TI - Fc Receptors AU - Daeron, Marc. AU - Nimmerjahn, Falk. PY - 2014 SN - 3319079115 3319079107 1322137064 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Cell receptors KW - Fc receptors KW - Structure-activity relationships. KW - Research. KW - Immunology. KW - Cell receptors. KW - Medicine. KW - Receptors. KW - Molecular Medicine. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Cell membrane receptors KW - Cell surface receptors KW - Receptors, Cell KW - Binding sites (Biochemistry) KW - Cell membranes KW - Proteins KW - Immunobiology KW - Serology KW - Health Workforce KW - Receptors, Fc KW - Lymphocytes KW - Macrophages KW - Structure-activity relationships (Biochemistry) KW - Proteins . KW - Molecular biology. KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Proteids KW - Polypeptides KW - Proteomics KW - Proteins. KW - Medicine KW - Biology KW - Biomedical Research. KW - Biological research KW - Biomedical research UR - https://www.unicat.be/uniCat?func=search&query=sysid:700868 AB - This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes. ER -