TY - BOOK ID - 698240 TI - Primary Aldosteronism : Molecular Genetics, Endocrinology, and Translational Medicine PY - 2014 SN - 1493905090 1493905082 PB - New York, NY : Springer New York : Imprint: Springer, DB - UniCat KW - Adrenal glands KW - Hypertension KW - Diseases. KW - Human genetics. KW - Endocrinology. KW - Medicine. KW - Human Genetics. KW - Biomedicine general. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Internal medicine KW - Hormones KW - Genetics KW - Heredity, Human KW - Physical anthropology KW - Health Workforce KW - Endocrinology . KW - Biomedicine, general. UR - https://www.unicat.be/uniCat?func=search&query=sysid:698240 AB - Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more. ER -