TY - BOOK ID - 65497713 TI - Molecular Targeted Radiosensitizers : Opportunities and Challenges AU - Willers, Henning. AU - Eke, Iris. PY - 2020 SN - 3030497011 3030497003 PB - Cham : Springer International Publishing : Imprint: Humana, DB - UniCat KW - Cancer research. KW - Radiotherapy. KW - Pharmacology. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemicals KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Radiation therapy KW - Electrotherapeutics KW - Hospitals KW - Medical electronics KW - Medical radiology KW - Therapeutics, Physiological KW - Phototherapy KW - Cancer research KW - Physiological effect KW - Radiological services KW - Radiation-sensitizing agents. KW - Radiation KW - Radiosensitizing agents KW - Sensitizing agents KW - Farmacologia KW - Investigació farmacèutica KW - Oncologia KW - Radiologia mèdica KW - Radiologia clínica KW - Radiologia (Medicina) KW - Física mèdica KW - Medicina nuclear KW - Radiofàrmacs KW - Radiografia mèdica KW - Radiologia dental KW - Radiologia intervencionista KW - Radiologia pediàtrica KW - Radiologia veterinària KW - Radioteràpia KW - Diagnòstic radiològic KW - Medicina KW - Oncologia geriàtrica KW - Oncologia pediàtrica KW - Oncologia veterinària KW - Càncer KW - Infermeria oncològica KW - Tumors KW - Investigació farmacològica KW - Investigació de medicaments KW - Recerca de medicaments KW - Investigació mèdica KW - Biofarmàcia KW - Biotransformació (Metabolisme) KW - Dermofarmacologia KW - Desenvolupament de medicaments KW - Estabilitat dels medicaments KW - Farmacocinètica KW - Farmacogenètica KW - Farmacologia cardiovascular KW - Farmacologia clínica KW - Farmacologia dental KW - Farmacologia geriàtrica KW - Farmacologia molecular KW - Farmacologia obstètrica KW - Farmacologia ocular KW - Farmacologia pediàtrica KW - Farmacologia respiratòria KW - Farmacologia renal KW - Farmacologia veterinària KW - Immunofarmacologia KW - Isòtops radioactius en farmacologia KW - Neurofarmacologia KW - Psicofarmacologia KW - Química farmacèutica KW - Resistència als medicaments KW - Toxicologia KW - Medicaments KW - Quimioteràpia KW - Fotofarmacologia UR - https://www.unicat.be/uniCat?func=search&query=sysid:65497713 AB - Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology. ER -