TY - BOOK ID - 65370744 TI - The M2 Macrophage PY - 2020 SN - 3030504808 3030504794 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Immunology. KW - Cell biology. KW - Lipids. KW - Infectious diseases. KW - Human physiology. KW - Cell Biology. KW - Lipidology. KW - Infectious Diseases. KW - Human Physiology. KW - Human biology KW - Medical sciences KW - Physiology KW - Human body KW - Lipides KW - Lipins KW - Lipoids KW - Biomolecules KW - Steroids KW - Cell biology KW - Cellular biology KW - Biology KW - Cells KW - Cytologists KW - Immunobiology KW - Life sciences KW - Serology KW - Macrophages. KW - Histiocytes KW - Mononuclear phagocytes KW - Antigen presenting cells KW - Connective tissue cells KW - Killer cells KW - Phagocytes KW - Reticulo-endothelial system KW - Communicable diseases. KW - Infection. UR - https://www.unicat.be/uniCat?func=search&query=sysid:65370744 AB - Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered. ER -