TY - BOOK ID - 64931085 TI - Natural Products and Drug Discovery PY - 2020 SN - 3039287478 303928746X PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - dihydrochalcones KW - cytotoxicity-guided KW - n/a KW - harpagoside KW - biotechnology KW - synergy KW - Imperata cylindrica KW - 5?-dimethylchalcone (DMC) KW - antioxidant activity KW - marine resources KW - phenolic derivatives KW - secondary metabolites KW - antimicrobial agents KW - antimicrobial resistance KW - metabolomics KW - Humulus lupulus KW - chromatography KW - stereochemistry KW - FSE KW - cytokines KW - cytotoxic activity KW - glutamate KW - angiogenesis KW - traditional medicine KW - Ca2+ KW - L6 cell KW - human colon cancer cell lines KW - siphonous green algae KW - anti-inflammatory activity KW - Phyllanthus chamacristoides KW - spectroscopic analysis KW - Physcomitrella patens KW - Leishmania mexicana mexicana KW - dementia KW - prenylated phenolic compounds KW - T2DM KW - HPLC-ESI-microTOF-Q-MS/MS KW - Eruca sativa KW - Dryopteris fragrans KW - chemosystematics KW - 2? KW - cerebellum KW - Cleistocalyx operculatus KW - inflammation KW - multivariate data analysis KW - Phyllanthus orbicularis KW - HPLC KW - cardiovascular disease KW - Kv7 potassium channels KW - marine peptides KW - proliferation KW - sulfated coumarins KW - Orobanche s.l. KW - phenylpropanoid glycosides KW - Harpagophytum procumbens KW - sesquiterpenoids KW - TRPV1 KW - Fideloside KW - phenylethanoid glycosides KW - Cuba KW - molecular network KW - NMR KW - ketamine KW - aging KW - GLUT4 KW - diabetes KW - oxidative stress KW - Lamiales KW - circular dichroism KW - psychosis KW - antinociceptive KW - immuno-regulation activity KW - terpenoids KW - NADPH oxidases KW - diabetic neuropathy KW - spagyric tincture KW - H2S KW - celastrol KW - isolation and quantification KW - 4?-dihydroxy-6?-methoxy-3? KW - Leea indica KW - C-glycoside KW - neuropathic pain KW - PANC-1 KW - glucosinolates KW - flavonoids KW - bioactivities of natural products KW - cardamonin KW - isoflavones KW - terpenes KW - methicillin-resistant Staphylococcus aureus KW - malaria KW - artemisinin KW - natural products KW - devil’s claw KW - ACE inhibitory peptide KW - pPancreatic cancer KW - growth inhibitory activity KW - mass spectrometry KW - flavonoid KW - phenolics KW - Astragalus boeticus L. KW - proanthocyanidins KW - opioid KW - Trifolium KW - Trypanosoma brucei brucei KW - acetylated astragalosides KW - Fabaceae KW - bioactive peptides KW - LC-MS KW - Dasycladus vermicularis KW - Orobanchaceae KW - migration KW - glucoerucin KW - ESI-MS/MS KW - cancer KW - zebrafish KW - antihypertensive KW - Bacopa monnieri KW - chemical derivatization KW - hypertension KW - devil's claw UR - https://www.unicat.be/uniCat?func=search&query=sysid:64931085 AB - Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays. ER -