TY - BOOK ID - 64904614 TI - Circulating Tumor Cells in Breast Cancer Metastatic Disease PY - 2020 SN - 3030358054 3030358046 PB - Cham : Springer International Publishing : Imprint: Springer, DB - UniCat KW - Cancer research. KW - Molecular biology. KW - Biomedical engineering. KW - Stem cells. KW - Cancer Research. KW - Molecular Medicine. KW - Biomedical Engineering/Biotechnology. KW - Stem Cells. KW - Colony-forming units (Cells) KW - Mother cells KW - Progenitor cells KW - Cells KW - Clinical engineering KW - Medical engineering KW - Bioengineering KW - Biophysics KW - Engineering KW - Medicine KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biomolecules KW - Systems biology KW - Cancer research KW - Breast KW - Breast Neoplasms. KW - Neoplasm Metastasis. KW - Neoplastic Cells, Circulating. KW - Cancer KW - Molecular aspects. KW - Cells, Neoplasm Circulating KW - Circulating Cells, Neoplasm KW - Circulating Tumor Cells KW - Circulating Neoplastic Cells KW - Embolic Tumor Cells KW - Embolism, Tumor KW - Neoplasm Circulating Cells KW - Tumor Cells, Embolic KW - Cell, Circulating Neoplastic KW - Cell, Circulating Tumor KW - Cell, Embolic Tumor KW - Cell, Neoplasm Circulating KW - Cells, Circulating Neoplastic KW - Cells, Circulating Tumor KW - Cells, Embolic Tumor KW - Circulating Neoplastic Cell KW - Circulating Tumor Cell KW - Embolic Tumor Cell KW - Embolisms, Tumor KW - Neoplasm Circulating Cell KW - Neoplastic Cell, Circulating KW - Tumor Cell, Circulating KW - Tumor Cell, Embolic KW - Tumor Cells, Circulating KW - Tumor Embolism KW - Tumor Embolisms KW - Metastases, Neoplasm KW - Metastasis, Neoplasm KW - Neoplasm Metastases KW - Metastasis KW - Metastases KW - Neoplasms KW - Breast Carcinoma KW - Cancer of the Breast KW - Human Mammary Carcinoma KW - Malignant Neoplasm of Breast KW - Malignant Tumor of Breast KW - Mammary Cancer KW - Mammary Carcinoma, Human KW - Mammary Neoplasm, Human KW - Mammary Neoplasms, Human KW - Neoplasms, Breast KW - Tumors, Breast KW - Breast Cancer KW - Breast Tumors KW - Cancer of Breast KW - Breast Carcinomas KW - Breast Malignant Neoplasm KW - Breast Malignant Neoplasms KW - Breast Malignant Tumor KW - Breast Malignant Tumors KW - Breast Neoplasm KW - Breast Tumor KW - Cancer, Breast KW - Cancer, Mammary KW - Cancers, Mammary KW - Carcinoma, Breast KW - Carcinoma, Human Mammary KW - Carcinomas, Breast KW - Carcinomas, Human Mammary KW - Human Mammary Carcinomas KW - Human Mammary Neoplasm KW - Human Mammary Neoplasms KW - Mammary Cancers KW - Mammary Carcinomas, Human KW - Neoplasm, Breast KW - Neoplasm, Human Mammary KW - Neoplasms, Human Mammary KW - Tumor, Breast KW - Breast Cancer Lymphedema KW - secondary KW - Càncer de mama KW - Cèl·lules canceroses KW - Monitoratge de pacients KW - Monitoratge fisiològic KW - Supervisió electrònica dels malalts KW - Supervisió electrònica dels pacients KW - Diagnòstic KW - Medicina intensiva KW - Monitoratge fetal KW - Cèl·lules KW - Patologia cel·lular KW - Metàstasi KW - Càncer KW - Càncer de pit KW - Malalties de la mama KW - Càncer ginecològic UR - https://www.unicat.be/uniCat?func=search&query=sysid:64904614 AB - This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer. ER -