TY - BOOK ID - 61157110 TI - Transmucosal Absorption Enhancers in the Drug Delivery Field AU - Maher, Sam AU - Illum, Lisbeth AU - Casettari, Luca PY - 2020 SN - 3039218492 3039218484 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - chitosan KW - intestinal epithelial cells KW - ocular delivery KW - amphiphilic polymers KW - cornea KW - tight junction modulator KW - cyclodextrin KW - permeability KW - gemini surfactant KW - transferrin KW - compound 48/80 KW - epithelial permeability KW - cervicovaginal tumors KW - nanoparticles KW - confocal laser scanning microscopy KW - safety KW - formulation KW - salcaprozate sodium KW - intestinal absorption KW - FITC-dextran KW - curcumin KW - block copolymers KW - nasal vaccination KW - whole leaf KW - brush border KW - ocular drug delivery KW - vaccine adjuvant KW - nanoparticle KW - nasal delivery KW - efflux KW - permeation enhancers KW - absorption enhancers KW - nose to brain delivery KW - small intestine KW - epithelium KW - CNS disorders KW - absorption modifying excipients KW - insulin KW - absorption enhancer KW - gel KW - intestinal delivery KW - thermogel system KW - Caco-2 KW - biocompatibility studies KW - absorption enhancement KW - man KW - PN159 KW - poorly absorbed drug KW - tryptophan KW - tight junction KW - oral macromolecule delivery KW - penetration enhancer KW - intestinal permeation enhancers KW - nanocrystals KW - simvastatin KW - nanomedicine KW - enterocyte KW - N-dodecyl-?-D-maltoside (DDM) KW - cell-penetrating peptide KW - quaternization KW - KLAL KW - nasal KW - nasal permeability KW - transmucosal drug delivery KW - Caco-2 cells KW - mast cell activator KW - penetration enhancers KW - drug delivery KW - nose-to-brain KW - bioenhancer KW - polymeric micelles KW - mucoadhesion KW - cell-penetrating peptide (CPP) KW - simulated intestinal fluid KW - vaginal delivery KW - nasal formulation KW - pharmacokinetic interaction KW - sodium caprate KW - clinical trial KW - transmucosal permeation KW - drug absorption enhancer KW - sugar-based surfactants KW - nanocapsules KW - imatinib KW - teriparatide KW - osteoporosis KW - hydrophobization KW - F-actin KW - combined microsphere KW - transepithelial electrical resistance KW - oral delivery KW - ocular conditions KW - metabolism KW - antimicrobial peptide KW - permeation enhancer KW - drug administration KW - antiepileptic drug KW - amino acid KW - in vivo studies KW - sodium cholate (NaC) KW - epithelial transport KW - preclinical KW - nose to brain transport KW - pharmacokinetics KW - chitosan derivatives KW - ophthalmology KW - tight junctions KW - sheep KW - cationic functionalization KW - GLP-1 KW - pulmonary KW - and liposome KW - cytochrome P450 KW - claudin KW - P-glycoprotein KW - in situ hydrogel KW - mucoadhesiveness KW - PTH 1-34 KW - Aloe vera KW - oral peptides UR - https://www.unicat.be/uniCat?func=search&query=sysid:61157110 AB - Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies. ER -