TY - BOOK ID - 61122627 TI - Genetic Determinants of Human Longevity AU - Rose, Giuseppina AU - Sørensen, Mette AU - Dato, Serena PY - 2019 SN - 3039216791 3039216783 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - unknown zygosity KW - exceptional longevity KW - TERC KW - xenobiotic-metabolizing enzymes KW - lifespan KW - gender-specific association KW - long-livers KW - polymorphism KW - cumulative incidence curves KW - cardiovascular health KW - twins KW - genetic determinants of human longevity KW - TERT KW - SNP KW - moonlighting protein KW - longevity KW - genomics KW - APOE KW - polygenic risk score KW - signal transduction KW - xenobiotics KW - survival KW - IPMK KW - genetic variation KW - genetic association study KW - molecular senescence KW - zygosity KW - longevity-related genes KW - age-stratification KW - lipid profile KW - mortality KW - apolipoprotein E KW - aging KW - model systems KW - leukocyte telomere length KW - inositol phosphates KW - human lifespan KW - populations UR - https://www.unicat.be/uniCat?func=search&query=sysid:61122627 AB - In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. ER -