TY - BOOK ID - 61121956 TI - Disease and the Hippo Pathway: Cellular and Molecular Mechanisms PY - 2019 SN - 3039217771 3039217763 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - STRIPAK KW - skin cancer KW - n/a KW - Lats2 KW - transcription KW - myofibroblast KW - epigenetic KW - Hippo KW - cancer immunity KW - TAZ KW - Taz KW - TAZ (transcriptional co-activator with PDZ-binding motif) KW - adaptive immunity KW - fibroblasts KW - innate immunity KW - LATS KW - MST (mammalian STE20-like protein kinase) KW - phosphorylation KW - stem cells KW - wound healing KW - signal transduction KW - angiogenesis KW - LATS1/2 KW - EMT KW - protein-protein interactions KW - structure biology KW - Hippo pathway KW - hippo pathway KW - autoimmunity KW - Mps one binder KW - YAP/TAZ KW - GPCR KW - fibrosis KW - MST1/2 KW - YAP (yes-associated protein) KW - YAP KW - Yap KW - protein kinase KW - LATS (large tumor suppressor kinase) KW - peripheral nerve sheath tumor KW - signal cross-talk KW - stem cell KW - skin development KW - STK38 KW - tumorigenesis KW - NDR KW - schwannoma KW - G protein-coupled receptor KW - anti-cancer therapy KW - feedback loops KW - vascular mimicry KW - castration resistance KW - chromatin KW - Hippo signalling KW - ECM KW - MST KW - prostate cancer KW - TEAD KW - cancer KW - zebrafish UR - https://www.unicat.be/uniCat?func=search&query=sysid:61121956 AB - The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies. ER -