TY - BOOK ID - 61121924 TI - Enzyme-Mediated Stereoselective Synthesis PY - 2019 SN - 3039219375 3039219367 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - enantioselective synthesis KW - flavors KW - n/a KW - hydroxy fatty acids KW - chiral amines KW - diketones KW - esters KW - oleic acid KW - Burkholderia cepacia lipase KW - multi-enzymatic cascades KW - solid-state fermentation KW - biocatalysis KW - agro-industrial side stream KW - rapeseed cake KW - enzyme-mediated resolution KW - linolenic acid KW - stereoselective biotransformation KW - lipases KW - kinetic resolution KW - 1-phenylethanol KW - linseed cake KW - bioreduction KW - Lactobacillus rhamnosus KW - alcohol-dehydrogenase KW - enantioselectivity KW - hydratase KW - reaction engineering KW - immobilization KW - ?-transaminases KW - linoleic acid KW - cyclization KW - monoterpenes KW - 1 KW - lactones KW - protein engineering KW - asymmetric synthesis KW - alcohol dehydrogenases KW - linaloyl oxide KW - chiral resolution KW - aroma compounds KW - 4-diols KW - pullulan KW - linalool KW - reduction KW - nitroketone UR - https://www.unicat.be/uniCat?func=search&query=sysid:61121924 AB - This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines. ER -