TY - BOOK ID - 5490175 TI - Quadruplex nucleic acids AU - Balasuramanian, Shankar AU - Campbell, Simon F. AU - Clore, Marius AU - Lilley, David M. J. AU - Neidle, Stephen AU - Royal society of chemistry (GB) PY - 2006 SN - 9780854043743 0854043748 PB - Cambridge : RSC Publishing, DB - UniCat KW - Molecular pharmacology KW - Molecular biology KW - Pharmacologie moléculaire KW - Biologie moléculaire KW - Quadruplex nucleic acids KW - Nucleic Acid Conformation KW - DNA KW - Genetic Structures KW - Nucleic Acids KW - Molecular Conformation KW - Genetic Phenomena KW - Nucleic Acids, Nucleotides, and Nucleosides KW - Molecular Structure KW - Chemicals and Drugs KW - Biochemical Phenomena KW - Phenomena and Processes KW - Chemical Phenomena KW - Animal Biochemistry KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Pharmacologie moléculaire KW - Biologie moléculaire UR - https://www.unicat.be/uniCat?func=search&query=sysid:5490175 AB - Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and ER -