TY - BOOK ID - 5479825 TI - RNA interference : from biology to clinical applications AU - Min, Wei-Ping AU - Ichim, Thomas PY - 2010 SN - 1607615886 1607615878 9781607615873 PB - New York, NY : Humana Press, DB - UniCat KW - RNA editing KW - Small interfering RNA KW - Gene silencing KW - RNA Interference KW - Gene Silencing KW - Epigenesis, Genetic KW - Gene Expression Regulation KW - Genetic Processes KW - Genetic Phenomena KW - Phenomena and Processes KW - Microbiology & Immunology KW - Animal Biochemistry KW - Genetics KW - Biology KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Gene Silencing. KW - RNA Interference. KW - RNA editing. KW - Gene silencing. KW - ARN KW - Inactivation génétique KW - Edition KW - Genetic Concepts KW - Genetic Phenomenon KW - Genetic Process KW - Concept, Genetic KW - Concepts, Genetic KW - Genetic Concept KW - Phenomena, Genetic KW - Phenomenon, Genetic KW - Process, Genetic KW - Processes, Genetic KW - Expression Regulation, Gene KW - Regulation, Gene Action KW - Regulation, Gene Expression KW - Gene Action Regulation KW - Regulation of Gene Expression KW - Epigenetic Process KW - Epigenetics Processes KW - Epigenetic Processes KW - Genetic Epigenesis KW - Process, Epigenetic KW - Processes, Epigenetic KW - Processes, Epigenetics KW - Gene Inactivation KW - Inactivation, Gene KW - Silencing, Gene KW - Co-Suppression KW - Cosuppression KW - Posttranscriptional Gene Silencing KW - RNA Silencing KW - RNAi KW - Gene Silencing, Post-Transcriptional KW - Post-Transcriptional Gene Silencing KW - Co Suppression KW - Gene Silencing, Post Transcriptional KW - Gene Silencing, Posttranscriptional KW - Gene Silencings, Posttranscriptional KW - Interference, RNA KW - Post Transcriptional Gene Silencing KW - Post-Transcriptional Gene Silencings KW - Silencing, Post-Transcriptional Gene KW - Gene inactivation KW - piRNA (Piwi-interacting RNA) KW - Piwi-interacting RNA KW - Piwi protein-interacting RNA KW - rasiRNA (Repeat-associated small interfering RNA) KW - Repeat-associated siRNA KW - Repeat-associated small interfering RNA KW - Scan RNA KW - scnRNA (Small scan RNA) KW - Short hairpin RNA KW - Short interfering RNA KW - shRNA (Short hairpin RNA) KW - siRNA (Small interfering RNA) KW - Small hairpin RNA KW - Small scan RNA KW - tasiRNA (Trans-acting small interfering RNA) KW - Trans-acting siRNA KW - Trans-acting small interfering RNA KW - Editing, RNA KW - Messenger RNA editing KW - mRNA editing KW - Immunology. KW - Medical laboratories. KW - Laboratory Medicine. KW - Diagnosis, Laboratory KW - Health facilities KW - Laboratories KW - Immunobiology KW - Life sciences KW - Serology KW - Medicine KW - Biomedical Research. KW - Biological research KW - Biomedical research KW - Health Workforce KW - Research. UR - https://www.unicat.be/uniCat?func=search&query=sysid:5479825 AB - From the early days when RNA interference was a strange artifact in worms to the 2006 Noble Prize received by Fire and Mello and the current clinical trials, the field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert contributors provide an overview of the most current science and protocols that span the biological disciplines from detailed nucleic acid chemistry, to pharmacology, to the manipulation of signal transduction pathways. Divided into three distinct sections, this volume delves into the physiology of RNA interference, RNA interference in the laboratory and siRNA delivery, and preclinical and clinical issues associated with the use of RNAi-inducing agents as drugs in order to stimulate new questions and offer the tools necessary to start addressing those questions. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and inspiring, RNA Interference: From Biology to Clinical Applications aims to promote and motivate innovation by reviewing what has been done, providing details of how it has been done, and encouraging speculation on what the future may hold. ER -