TY - BOOK ID - 5453936 TI - Recombination and Meiosis : Crossing-Over and Disjunction AU - Egel, Richard. AU - Lankenau, Dirk-Henner. PY - 2008 SN - 9783540753711 3540753710 3642094597 3540753737 PB - Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, DB - UniCat KW - Recombination, Genetic. KW - Meiosis. KW - Genetic recombination. KW - Crossing over (Genetics) KW - Recombinaison génétique KW - Méiose KW - Meiosis KW - Recombination, Genetic KW - Genetic Processes KW - Cell Nucleus Division KW - Cell Division KW - Genetic Phenomena KW - Phenomena and Processes KW - Cell Cycle KW - Cell Physiological Processes KW - Cell Physiological Phenomena KW - Cytology KW - Genetics KW - Biology KW - Health & Biological Sciences KW - Reduction division (Genetics) KW - Life sciences. KW - Human genetics. KW - Biochemistry. KW - Cell biology. KW - Plant genetics. KW - Animal genetics. KW - Life Sciences. KW - Cell Biology. KW - Biochemistry, general. KW - Animal Genetics and Genomics. KW - Human Genetics. KW - Plant Genetics & Genomics. KW - Cell division KW - Karyokinesis KW - Genetic recombination KW - Translocation (Genetics) KW - Chromosomes KW - Recombinant DNA KW - Cytology. KW - Plant Genetics and Genomics. KW - Plants KW - Heredity, Human KW - Human biology KW - Physical anthropology KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Medical sciences KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Composition UR - https://www.unicat.be/uniCat?func=search&query=sysid:5453936 AB - Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Central to mainstream meiosis, the mechanisms of reciprocal exchange at crossover/chiasma sites stand out as a controlled program of biologically significant molecular changes. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that is subsequently repaired by homologous recombination. These key events are accompanied by ancillary provisions at the level of chromosome core organization, sister chromatid cohesion, and differential centromere connectivity. Great progress has been made in recent years to further our understanding of these mechanisms. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Arabidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume. ER -