TY - BOOK ID - 5452052 TI - Molecular Biology of Metal Homeostasis and Detoxification : From Microbes to Man AU - Tamás, Markus J. AU - Martinoia, Enrico. PY - 2006 VL - 14 SN - 16102096 SN - 9783540221753 3540221751 3540317198 PB - Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, DB - UniCat KW - Metalloproteins KW - Metals KW - Homeostasis KW - Molecular Biology KW - Metal ions KW - Molecular genetics KW - Métalloprotéines KW - Génétique moléculaire KW - Homéostasie KW - metabolism KW - Metabolism KW - Metabolic detoxification KW - Physiological Processes KW - Proteins KW - Biochemistry KW - Inorganic Chemicals KW - Genetics KW - Biological Science Disciplines KW - Chemistry KW - Biology KW - Amino Acids, Peptides, and Proteins KW - Chemicals and Drugs KW - Physiological Phenomena KW - Natural Science Disciplines KW - Phenomena and Processes KW - Disciplines and Occupations KW - Biology - General KW - Animal Biochemistry KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Physical Sciences & Mathematics KW - Disorders KW - Metal KW - Metabolic detoxification. KW - Disorders. KW - Metabolism. KW - Metallic elements KW - Life sciences. KW - Biochemistry. KW - Cell biology. KW - Microbiology. KW - Plant physiology. KW - Life Sciences. KW - Biochemistry, general. KW - Cell Biology. KW - Biomedicine general. KW - Plant Physiology. KW - Chemical elements KW - Ores KW - Metallurgy KW - Cytology. KW - Medicine. KW - Botany KW - Plants KW - Physiology KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Microbial biology KW - Microorganisms KW - Cell biology KW - Cellular biology KW - Cells KW - Cytologists KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Composition KW - Health Workforce KW - Biomedicine, general. KW - Medicine KW - Biomedical Research. KW - Research. KW - Biological research KW - Biomedical research UR - https://www.unicat.be/uniCat?func=search&query=sysid:5452052 AB - One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease. ER -