TY - BOOK ID - 5451600 TI - Histone Deacetylases : Transcriptional Regulation and Other Cellular Functions PY - 2006 SN - 9781588294999 1588294994 9781597450249 1617376027 9786610358526 1280358521 1597450243 PB - Totowa, NJ : Humana Press : Imprint: Humana, DB - UniCat KW - Histone Deacetylases KW - Cell Cycle KW - Enzyme Repression KW - Neoplasms KW - Sirtuins KW - Histone deacetylase. KW - Cell cycle. KW - Enzymes. KW - Cancer KW - Histone désacétylase KW - Cycle cellulaire KW - Enzymes KW - physiology. KW - drug effects. KW - antagonists & inhibitors. KW - drug therapy. KW - Chemotherapy. KW - Chimiothérapie KW - Cancer -- Chemotherapy. KW - Histone deacetylase KW - Cell cycle KW - Cell Physiological Processes KW - Gene Expression Regulation, Enzymologic KW - Enzyme Inhibitors KW - ADP Ribose Transferases KW - Amidohydrolases KW - Group III Histone Deacetylases KW - Biological Science Disciplines KW - Intracellular Signaling Peptides and Proteins KW - Diseases KW - Therapeutics KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Natural Science Disciplines KW - Molecular Mechanisms of Pharmacological Action KW - Pentosyltransferases KW - Proteins KW - Gene Expression Regulation KW - Cell Physiological Phenomena KW - Hydrolases KW - Disciplines and Occupations KW - Glycosyltransferases KW - Amino Acids, Peptides, and Proteins KW - Pharmacologic Actions KW - Phenomena and Processes KW - Genetic Processes KW - Transferases KW - Chemical Actions and Uses KW - Enzymes and Coenzymes KW - Genetic Phenomena KW - Chemicals and Drugs KW - Drug Therapy KW - Histone Deacetylase Inhibitors KW - Physiology KW - Human Anatomy & Physiology KW - Medicine KW - Health & Biological Sciences KW - Animal Biochemistry KW - Oncology KW - Chemotherapy KW - Biocatalysts KW - Ferments KW - Soluble ferments KW - Mitotic cycle KW - Nuclear cycle (Cytology) KW - Medicine. KW - Cancer research. KW - Biomedicine. KW - Cancer Research. KW - Antineoplastic agents KW - Catalysts KW - Enzymology KW - Biological rhythms KW - Amidases KW - Treatment KW - Oncology. KW - Tumors KW - Cancer research UR - https://www.unicat.be/uniCat?func=search&query=sysid:5451600 AB - The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come. ER -