TY - BOOK ID - 5450571 TI - Oncogenomics handbook AU - LaRochelle, William J. AU - Shimkets, Richard A. PY - 2005 SN - 9781588294258 1588294250 9781592598939 9786610359288 1280359285 1592598935 PB - Totowa, N.J. : Humana Press, DB - UniCat KW - Cancer KW - Oncogenes KW - Genomics KW - Proteomics KW - Oncogènes KW - Génomique KW - Protéomique KW - Genetic aspects KW - Handbooks, manuals, etc. KW - Aspect génétique KW - Guides, manuels, etc. KW - Cancer -- Genetic aspects -- Handbooks, manuals, etc. KW - Genomics -- Handbooks, manuals, etc. KW - Oncogenes -- Handbooks, manuals, etc. KW - Proteomics -- Handbooks, manuals, etc. KW - Genes, Neoplasm KW - Diseases KW - Biology KW - Computational Biology KW - Genes KW - Biological Science Disciplines KW - Genome Components KW - Natural Science Disciplines KW - Disciplines and Occupations KW - Genome KW - Genetic Structures KW - Genetic Phenomena KW - Phenomena and Processes KW - Genetics KW - Neoplasms KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Genome research KW - Genomes KW - Onc genes KW - Cancers KW - Carcinoma KW - Malignancy (Cancer) KW - Malignant tumors KW - Research KW - Medicine. KW - Oncology. KW - Medicine & Public Health. KW - Tumors KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Molecular biology KW - Proteins KW - Molecular genetics KW - Cancer genes KW - Proto-oncogenes KW - Oncology  . UR - https://www.unicat.be/uniCat?func=search&query=sysid:5450571 AB - Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development. ER -