TY - BOOK ID - 5450540 TI - Camptothecins in cancer therapy AU - Burke, Thomas G. AU - Adams, Val R. PY - 2005 SN - 9781588290274 1588290271 9781592598663 9786610359509 1280359501 1592598668 1627038167 PB - Totowa, N.J. : Humana Press, DB - UniCat KW - Camptothecin KW - Neoplasms KW - Antineoplastic Agents, Phytogenic KW - Camptothecin. KW - Cancer KW - therapeutic use. KW - drug therapy. KW - analogs & derivatives. KW - pharmacology. KW - Chemotherapy. KW - Chimiothérapie KW - Chemotherapy KW - therapeutic use KW - drug therapy KW - analogs and derivatives KW - pharmacology KW - Cancer -- Chemotherapy. KW - Alkaloids KW - Diseases KW - Therapeutics KW - Antineoplastic Agents KW - Biological Science Disciplines KW - Therapeutic Uses KW - Natural Science Disciplines KW - Heterocyclic Compounds KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Disciplines and Occupations KW - Chemicals and Drugs KW - Pharmacologic Actions KW - Chemical Actions and Uses KW - Pharmacology KW - Drug Therapy KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Medicine. KW - Oncology. KW - Medicine & Public Health. KW - Tumors KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Antineoplastic agents KW - Antiviral agents KW - Treatment KW - Oncology . KW - Cancer - Chemotherapy KW - Camptothecin - therapeutic use KW - Neoplasms - drug therapy KW - Antineoplastic Agents, Phytogenic - therapeutic use KW - Camptothecin - analogs and derivatives KW - Camptothecin - pharmacology UR - https://www.unicat.be/uniCat?func=search&query=sysid:5450540 AB - Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications. ER -